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2uzj
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2uzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2uzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZJ FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E64:N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE'>E64</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uzj OCA], [https://pdbe.org/2uzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uzj RCSB], [https://www.ebi.ac.uk/pdbsum/2uzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uzj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uzj OCA], [https://pdbe.org/2uzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uzj RCSB], [https://www.ebi.ac.uk/pdbsum/2uzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uzj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SPEB_STRPY SPEB_STRPY] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:9864206</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
| - | + | [[Category: Dagil R]] | |
| - | [[Category: Dagil | + | [[Category: Kragelund BB]] |
| - | [[Category: Kragelund | + | [[Category: Niclasen LM]] |
| - | [[Category: Niclasen | + | [[Category: Olsen JG]] |
| - | [[Category: Olsen | + | [[Category: Soerensen OE]] |
| - | [[Category: Soerensen | + | |
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Current revision
Crystal structure of the mature streptococcal cysteine protease, mSpeB
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