2v5z

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<StructureSection load='2v5z' size='340' side='right'caption='[[2v5z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2v5z' size='340' side='right'caption='[[2v5z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SAG:(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]'>SAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SAG:(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]'>SAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gos|1gos]], [[1h8r|1h8r]], [[1oj9|1oj9]], [[1oja|1oja]], [[1ojb|1ojb]], [[1ojc|1ojc]], [[1ojd|1ojd]], [[1s2q|1s2q]], [[1s2y|1s2y]], [[1s3b|1s3b]], [[1s3e|1s3e]], [[2bk3|2bk3]], [[2bk4|2bk4]], [[2bk5|2bk5]], [[2byb|2byb]], [[2c64|2c64]], [[2c65|2c65]], [[2c66|2c66]], [[2c67|2c67]], [[2c70|2c70]], [[2c72|2c72]], [[2c73|2c73]], [[2c75|2c75]], [[2c76|2c76]]</div></td></tr>
 
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5z OCA], [https://pdbe.org/2v5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5z RCSB], [https://www.ebi.ac.uk/pdbsum/2v5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5z OCA], [https://pdbe.org/2v5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5z RCSB], [https://www.ebi.ac.uk/pdbsum/2v5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5z ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Monoamine oxidase]]
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[[Category: Binda C]]
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[[Category: Binda, C]]
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[[Category: Caccia C]]
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[[Category: Caccia, C]]
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[[Category: Carotti A]]
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[[Category: Carotti, A]]
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[[Category: Edmondson DE]]
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[[Category: Edmondson, D E]]
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[[Category: Mattevi A]]
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[[Category: Mattevi, A]]
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[[Category: Pisani L]]
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[[Category: Pisani, L]]
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[[Category: Salvati P]]
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[[Category: Salvati, P]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Human mao b structure]]
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[[Category: Membrane]]
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[[Category: Mitochondrion]]
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[[Category: Neuroprotection]]
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[[Category: Oxidoreductase]]
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[[Category: Parkinson's disease]]
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[[Category: Reversible inhibitor binding]]
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[[Category: Safinamide]]
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[[Category: Transmembrane]]
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Revision as of 07:39, 18 January 2023

Structure of human MAO B in complex with the selective inhibitor safinamide

PDB ID 2v5z

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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