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2v76
From Proteopedia
(Difference between revisions)
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<StructureSection load='2v76' size='340' side='right'caption='[[2v76]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='2v76' size='340' side='right'caption='[[2v76]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2v76]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2v76]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V76 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v76 OCA], [https://pdbe.org/2v76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v76 RCSB], [https://www.ebi.ac.uk/pdbsum/2v76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v76 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v76 OCA], [https://pdbe.org/2v76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v76 RCSB], [https://www.ebi.ac.uk/pdbsum/2v76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v76 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOK1_HUMAN DOK1_HUMAN] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.<ref>PMID:18156175</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Anthis | + | [[Category: Anthis NJ]] |
| - | [[Category: Campbell | + | [[Category: Campbell ID]] |
| - | [[Category: Lowe | + | [[Category: Lowe ED]] |
| - | [[Category: Oxley | + | [[Category: Oxley CL]] |
| - | [[Category: Wegener | + | [[Category: Wegener KL]] |
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Current revision
Crystal structure of the human dok1 PTB domain
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