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2vbv

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Current revision (15:14, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2vbv' size='340' side='right'caption='[[2vbv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2vbv' size='340' side='right'caption='[[2vbv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vbv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vbv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2p3m|2p3m]], [[2vbs|2vbs]], [[2vbt|2vbt]], [[2vbu|2vbu]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/CTP-dependent_riboflavin_kinase CTP-dependent riboflavin kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.161 2.7.1.161] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbv OCA], [https://pdbe.org/2vbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbv RCSB], [https://www.ebi.ac.uk/pdbsum/2vbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbv OCA], [https://pdbe.org/2vbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbv RCSB], [https://www.ebi.ac.uk/pdbsum/2vbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RIFK_METJA RIFK_METJA]] Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates (PubMed:18245297) or not (PubMed:18073108).<ref>PMID:18073108</ref> <ref>PMID:18245297</ref>
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[https://www.uniprot.org/uniprot/RIFK_METJA RIFK_METJA] Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates (PubMed:18245297) or not (PubMed:18073108).<ref>PMID:18073108</ref> <ref>PMID:18245297</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43067]]
 
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[[Category: CTP-dependent riboflavin kinase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ammelburg, M]]
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[[Category: Methanocaldococcus jannaschii]]
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[[Category: Djuranovic, S]]
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[[Category: Ammelburg M]]
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[[Category: Hartmann, M D]]
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[[Category: Djuranovic S]]
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[[Category: Lupas, A N]]
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[[Category: Hartmann MD]]
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[[Category: Martin, J]]
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[[Category: Lupas AN]]
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[[Category: Zeth, K]]
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[[Category: Martin J]]
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[[Category: Cradle-loop barrel]]
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[[Category: Zeth K]]
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[[Category: Ctp-dependent kinase]]
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[[Category: Fmn]]
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[[Category: Transferase]]
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Current revision

Riboflavin kinase Mj0056 from Methanocaldococcus jannaschii in complex with CDP and FMN

PDB ID 2vbv

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