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3hem
From Proteopedia
(Difference between revisions)
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<StructureSection load='3hem' size='340' side='right'caption='[[3hem]], [[Resolution|resolution]] 2.39Å' scene=''> | <StructureSection load='3hem' size='340' side='right'caption='[[3hem]], [[Resolution|resolution]] 2.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3hem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HEM FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=D22:N-OCTYLOCTAN-1-AMINE'>D22</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hem OCA], [https://pdbe.org/3hem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hem RCSB], [https://www.ebi.ac.uk/pdbsum/3hem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hem ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hem OCA], [https://pdbe.org/3hem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hem RCSB], [https://www.ebi.ac.uk/pdbsum/3hem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hem ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CMAS2_MYCTU CMAS2_MYCTU] Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:11092877</ref> <ref>PMID:7592990</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]] | *[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cyclopropane-fatty-acyl-phospholipid synthase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis]] |
| - | [[Category: | + | [[Category: Liu Z]] |
| - | [[Category: | + | [[Category: Sacchettini JC]] |
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Current revision
Structure of Mycobacterium tuberculosis Mycolic Acid Cyclopropane Synthase CmaA2 in Complex with Dioctylamine
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