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3hhz

From Proteopedia

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Current revision (07:21, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3hhz' size='340' side='right'caption='[[3hhz]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='3hhz' size='340' side='right'caption='[[3hhz]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hhz]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Vsiv Vsiv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hhz]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Vesicular_stomatitis_Indiana_virus Vesicular stomatitis Indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHZ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hhw|3hhw]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nucleocapsid protein, P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11277 VSIV]), N, phosphoprotein ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11277 VSIV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhz OCA], [https://pdbe.org/3hhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhz RCSB], [https://www.ebi.ac.uk/pdbsum/3hhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhz OCA], [https://pdbe.org/3hhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhz RCSB], [https://www.ebi.ac.uk/pdbsum/3hhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PHOSP_VSIVM PHOSP_VSIVM]] Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template. May act as a chaperone for newly synthesized free N protein, so-called N(0). Plays a role in virion assembly (By similarity). [[https://www.uniprot.org/uniprot/NCAP_VSIVN NCAP_VSIVN]] Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Replication is dependent on intracellular concentration of newly synthesized N, termed N(0), which corresponds to the protein not associated with RNA. In contrast, when associated with RNA, it is termed N. During replication, encapsidation by N(0) is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
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[https://www.uniprot.org/uniprot/PHOSP_VSIVM PHOSP_VSIVM] Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template. May act as a chaperone for newly synthesized free N protein, so-called N(0). Plays a role in virion assembly (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vsiv]]
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[[Category: Vesicular stomatitis Indiana virus]]
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[[Category: Green, T J]]
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[[Category: Green TJ]]
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[[Category: Luo, M]]
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[[Category: Luo M]]
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[[Category: Chaperone]]
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[[Category: Negative strand rna virus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein]]
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[[Category: Replication]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna]]
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[[Category: Rna replication]]
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[[Category: Rna-binding]]
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[[Category: Template]]
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[[Category: Viral nucleoprotein]]
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[[Category: Viral protein]]
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[[Category: Viral protein-rna complex]]
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[[Category: Virion]]
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Current revision

Complex of the vesicular stomatitis virus nucleocapsid and the nucleocapsid-binding domain of the phosphoprotein

PDB ID 3hhz

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