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3hkc

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Current revision (15:50, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3hkc' size='340' side='right'caption='[[3hkc]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<StructureSection load='3hkc' size='340' side='right'caption='[[3hkc]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hkc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hkc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E70:N-{2-[(4-HYDROXYPHENYL)AMINO]PYRIDIN-3-YL}-4-METHOXYBENZENESULFONAMIDE'>E70</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sa0|1sa0]], [[1sa1|1sa1]], [[3hkb|3hkb]], [[3hkd|3hkd]], [[3hke|3hke]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E70:N-{2-[(4-HYDROXYPHENYL)AMINO]PYRIDIN-3-YL}-4-METHOXYBENZENESULFONAMIDE'>E70</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STMN4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkc OCA], [https://pdbe.org/3hkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hkc RCSB], [https://www.ebi.ac.uk/pdbsum/3hkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkc OCA], [https://pdbe.org/3hkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hkc RCSB], [https://www.ebi.ac.uk/pdbsum/3hkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
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[https://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Dorleans, A]]
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[[Category: Rattus norvegicus]]
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[[Category: Gigant, B]]
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[[Category: Dorleans A]]
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[[Category: Knossow, M]]
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[[Category: Gigant B]]
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[[Category: Mailliet, P]]
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[[Category: Knossow M]]
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[[Category: Mikol, V]]
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[[Category: Mailliet P]]
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[[Category: Ravelli, R B.G]]
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[[Category: Mikol V]]
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[[Category: Alpha-tubulin]]
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[[Category: Ravelli RBG]]
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[[Category: Beta-tubulin]]
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[[Category: Cell cycle]]
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[[Category: Colchicine domain]]
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[[Category: Gtpase microtubule]]
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[[Category: Stathmin]]
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[[Category: Tubulin]]
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Current revision

Tubulin-ABT751: RB3 stathmin-like domain complex

PDB ID 3hkc

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