Sandbox Reserved 1701

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==== DRY/ ERC Motif ====
==== DRY/ ERC Motif ====
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MRGPRX2 has an <scene name='90/904306/Erc_motif_3/1'>ERC Motif</scene> rather than the typically [https://proteopedia.org/wiki/index.php/A_Physical_Model_of_the_%CE%B22-Adrenergic_Receptor#conserved%20DRY%20motif conserved E/DRY Motif]. The amino acid residue shift from TYR-174 to CYS-128 has spatial arrangement implications where the helices are more compact in MRGPRX2 without the TYR to physically push the TMP helices apart.[[Image:Screen Shot 2022-03-15 at 10.23.20 AM.png|200px|left|thumb|ERC Motif]]
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MRGPRX2 has an <scene name='90/904306/Erc_motif_3/1'>ERC Motif</scene> rather than the typically [https://proteopedia.org/wiki/index.php/A_Physical_Model_of_the_%CE%B22-Adrenergic_Receptor#conserved%20DRY%20motif conserved E/DRY Motif]. The amino acid residue shift from TYR-174 to CYS-128 has spatial arrangement implications where the helices are more compact in MRGPRX2 without the TYR to physically push the TMP helices apart.
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[[Image:Screen Shot 2022-03-15 at 10.23.20 AM.png|200px|left|thumb|ERC Motif]]
==== Sodium Site ====
==== Sodium Site ====
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The MRGPRX2 <scene name='90/904306/Sodium_site_2/1'>sodium binding site</scene> consists of ASP-75 and GLY-116 compared to the [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium%20binding%20pocket previously conserved] residues in this binding pocket. Other class A GPCRs demonstrate a larger binding pocket with a higher negative character allowing for a suitable environment for sodium ions to bind. In MRGPRX2, this pocket lacks the same negative character and the helices are more collapsed making this binding pocket less accessible for sodium ions.
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The MRGPRX2 <scene name='90/904306/Sodium_site_2/1'>sodium binding site</scene> consists of ASP-75 and GLY-116 compared to the [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium%20binding%20pocket previously conserved] residues in this binding pocket. Other class A GPCRs demonstrate a larger binding pocket with a higher negative character allowing for a suitable environment for sodium ions to bind. In MRGPRX2, this pocket lacks the same amount of <scene name='90/904306/Sodium_site_charge/1'>negative character</scene> and the helices are more collapsed making this binding pocket less accessible for sodium ions.
==== Disulfide Bonds ====
==== Disulfide Bonds ====

Revision as of 20:20, 27 March 2022

This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729.
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MRGPRX2 Human Itch G-Protein Coupled Receptor (GPCR)

Human Itch GPCR Structure. Transmembrane protein shown in red, alpha subunit in blue, beta subunit in magenta, and gamma subunit in yellow.

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