Sandbox Reserved 1701

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==== Sodium Site ====
==== Sodium Site ====
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The MRGPRX2 <scene name='90/904306/Sodium_site_2/1'>sodium binding site</scene> consists of ASP-75 and GLY-116 compared to the [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium%20binding%20pocket previously conserved] residues in this binding pocket. Other class A GPCRs demonstrate a larger binding pocket with a higher negative character allowing for a suitable environment for sodium ions to bind. In MRGPRX2, this pocket lacks the same amount of <scene name='90/904306/Sodium_site_charge/1'>negative character</scene> and the helices are more collapsed making this binding pocket less accessible for sodium ions.
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The MRGPRX2 <scene name='90/904306/Sodium_site_2/1'>sodium binding site</scene> consists of ASP-75 and GLY-116 compared to the [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium%20binding%20pocket previously conserved] residues in this binding pocket. Other class A GPCRs demonstrate a larger binding pocket with a higher negative character allowing for a suitable environment for sodium ions to bind. In MRGPRX2, this pocket lacks the same amount of <scene name='90/904306/Sodium_site_charge/2'>negative character</scene> with the shift to a glycine residue rather than typical negative residues. The helices for the MRGPRX2 in the binding pocket are also more collapsed making this pocket less accessible for sodium ions.
==== Disulfide Bonds ====
==== Disulfide Bonds ====

Revision as of 20:27, 27 March 2022

This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

MRGPRX2 Human Itch G-Protein Coupled Receptor (GPCR)

Human Itch GPCR Structure. Transmembrane protein shown in red, alpha subunit in blue, beta subunit in magenta, and gamma subunit in yellow.

Drag the structure with the mouse to rotate
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