1gq0

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{{STRUCTURE_1gq0| PDB=1gq0 | SCENE= }}
{{STRUCTURE_1gq0| PDB=1gq0 | SCENE= }}
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'''SOLUTION STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE CHANNEL-FORMING POLYPEPTIDE; NMR, 20 STRUCTURES'''
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===SOLUTION STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE CHANNEL-FORMING POLYPEPTIDE; NMR, 20 STRUCTURES===
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==Overview==
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Antiamoebin I is a membrane-active peptaibol produced by fungi of the species Emericellopsis which is capable of forming ion channels in membranes. Previous structure determinations by x-ray crystallography have shown the molecule is mostly helical, with a deep bend in the center of the polypeptide, and that the backbone structure is independent of the solvent used for crystallization. In this study, the solution structure of antiamoebin was determined by NMR spectroscopy in methanol, a solvent from which one of the crystal structures was determined. The ensemble of structures produced exhibit a right-handed helical C terminus and a left-handed helical conformation toward the N-terminus, in contrast to the completely right-handed helices found in the crystal structures. The NMR results also suggest that a "hinge" region exists, which gives flexibility to the polypeptide in the central region, and which could have functional implications for the membrane insertion process. A model for the membrane insertion and assembly process is proposed based on the antiamoebin solution and crystal structures, and is contrasted with the assembly and insertion mechanism proposed for other ion channel-forming polypeptides.
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(as it appears on PubMed at http://www.pubmed.gov), where 12524274 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12524274}}
==About this Structure==
==About this Structure==
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1GQ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Emericellopsis_sp. Emericellopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ0 OCA].
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1GQ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Emericellopsis_sp. Emericellopsis sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ0 OCA].
==Reference==
==Reference==
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[[Category: Membrane polypeptide]]
[[Category: Membrane polypeptide]]
[[Category: Peptaibol]]
[[Category: Peptaibol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:52:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:45:19 2008''

Revision as of 02:45, 1 July 2008

Image:1gq0.png

Template:STRUCTURE 1gq0

SOLUTION STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE CHANNEL-FORMING POLYPEPTIDE; NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 12524274

About this Structure

1GQ0 is a Single protein structure of sequence from Emericellopsis sp.. Full experimental information is available from OCA.

Reference

Solution NMR studies of antiamoebin, a membrane channel-forming polypeptide., Galbraith TP, Harris R, Driscoll PC, Wallace BA, Biophys J. 2003 Jan;84(1):185-94. PMID:12524274

Page seeded by OCA on Tue Jul 1 05:45:19 2008

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