1e7h
From Proteopedia
(New page: 200px<br /> <applet load="1e7h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e7h, resolution 2.43Å" /> '''HUMAN SERUM ALBUMIN...) |
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caption="1e7h, resolution 2.43Å" /> | caption="1e7h, resolution 2.43Å" /> | ||
'''HUMAN SERUM ALBUMIN COMPLEXED WITH HEXADECANOIC ACID (PALMITIC ACID)'''<br /> | '''HUMAN SERUM ALBUMIN COMPLEXED WITH HEXADECANOIC ACID (PALMITIC ACID)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1E7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PLM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1E7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PLM:'>PLM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E7H OCA]. |
==Reference== | ==Reference== | ||
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[[Category: plasma protein]] | [[Category: plasma protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:41:45 2008'' |
Revision as of 13:41, 15 February 2008
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HUMAN SERUM ALBUMIN COMPLEXED WITH HEXADECANOIC ACID (PALMITIC ACID)
Contents |
Overview
Human serum albumin (HSA) is an abundant plasma protein that is, responsible for the transport of fatty acids. HSA also binds and perturbs, the pharmacokinetics of a wide range of drug compounds. Binding studies, have revealed significant interactions between fatty acid and drug-binding, sites on albumin but high-resolution structural information on ligand, binding to the protein has been lacking. We report here a crystallographic, study of five HSA-fatty acid complexes formed using saturated medium-chain, and long-chain fatty acids (C10:0, C12:0, C14:0, C16:0 and C18:0). A total, of seven binding sites that are occupied by all medium-chain and, long-chain fatty acids have been identified, although medium-chain fatty, acids are found to bind at additional sites on the protein, yielding a, total of 11 distinct binding locations. Comparison of the different, complexes reveals key similarities and significant differences in the, modes of binding, and serves to rationalise much of the biochemical data, on fatty acid interactions with albumin. The two principal drug-binding, sites, in sub-domains IIA and IIIA, are observed to be occupied by fatty, acids and one of them (in IIIA) appears to coincide with a high-affinity, long-chain fatty acid binding site.
Disease
Known diseases associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]
About this Structure
1E7H is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin., Bhattacharya AA, Grune T, Curry S, J Mol Biol. 2000 Nov 10;303(5):721-32. PMID:11061971
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