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6tar
From Proteopedia
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<SX load='6tar' size='340' side='right' viewer='molstar' caption='[[6tar]], [[Resolution|resolution]] 2.80Å' scene=''> | <SX load='6tar' size='340' side='right' viewer='molstar' caption='[[6tar]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6tar]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[6tar]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tar OCA], [https://pdbe.org/6tar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tar RCSB], [https://www.ebi.ac.uk/pdbsum/6tar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tar ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tar OCA], [https://pdbe.org/6tar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tar RCSB], [https://www.ebi.ac.uk/pdbsum/6tar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tar ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
| - | [[Category: | + | [[Category: Drosophila melanogaster]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Briggs | + | [[Category: Briggs JAG]] |
| - | [[Category: Erlendsson | + | [[Category: Erlendsson S]] |
| - | [[Category: Morado | + | [[Category: Morado DR]] |
| - | [[Category: Shepherd | + | [[Category: Shepherd JD]] |
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Current revision
Structure of the five-fold capsomer of the dArc1 capsid
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