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7rw5

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Current revision (16:39, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7rw5' size='340' side='right'caption='[[7rw5]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
<StructureSection load='7rw5' size='340' side='right'caption='[[7rw5]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7rw5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RW5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7rw5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RW5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7U2:(3R)-N-(cyclopropylmethyl)-1-[(2-fluorophenyl)methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3-pyrrolidin]-2-amine'>7U2</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7kcc|7kcc]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7U2:(3R)-N-(cyclopropylmethyl)-1-[(2-fluorophenyl)methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3-pyrrolidin]-2-amine'>7U2</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rw5 OCA], [https://pdbe.org/7rw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rw5 RCSB], [https://www.ebi.ac.uk/pdbsum/7rw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rw5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rw5 OCA], [https://pdbe.org/7rw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rw5 RCSB], [https://www.ebi.ac.uk/pdbsum/7rw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rw5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
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[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methionine adenosyltransferase]]
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[[Category: Jin L]]
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[[Category: Jin, L]]
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[[Category: Padyana AK]]
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[[Category: Padyana, A K]]
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[[Category: Allosteric inhibitor]]
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[[Category: Sam]]
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[[Category: Transferase]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 1

PDB ID 7rw5

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