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2w3o

From Proteopedia

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Current revision (15:42, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2w3o' size='340' side='right'caption='[[2w3o]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='2w3o' size='340' side='right'caption='[[2w3o]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w3o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w3o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cdz|1cdz]], [[1xnt|1xnt]], [[2brf|2brf]], [[1xna|1xna]], [[2d8m|2d8m]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3o OCA], [https://pdbe.org/2w3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3o RCSB], [https://www.ebi.ac.uk/pdbsum/2w3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3o OCA], [https://pdbe.org/2w3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3o RCSB], [https://www.ebi.ac.uk/pdbsum/2w3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/XRCC1_HUMAN XRCC1_HUMAN]] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
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[https://www.uniprot.org/uniprot/XRCC1_HUMAN XRCC1_HUMAN] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ali, A A.E]]
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[[Category: Ali AAE]]
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[[Category: Oliver, A W]]
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[[Category: Oliver AW]]
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[[Category: Pearl, L H]]
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[[Category: Pearl LH]]
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[[Category: Atp-binding]]
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[[Category: Base excision repair]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Fha]]
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[[Category: Hydrolase]]
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[[Category: Kinase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phospho- peptide]]
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[[Category: Phosphoprotein]]
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[[Category: Pnkp]]
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[[Category: Polymorphism]]
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[[Category: Polynucleotide kinase 3' phosphatase]]
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[[Category: Transferase]]
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[[Category: Transferase-peptide complex]]
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[[Category: Transferase/peptide]]
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[[Category: Xrcc1]]
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Current revision

Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide

PDB ID 2w3o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

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