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3hqy

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Current revision (07:27, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3hqy' size='340' side='right'caption='[[3hqy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3hqy' size='340' side='right'caption='[[3hqy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PF6:2-({4-[4-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-3-YL]PHENOXY}METHYL)QUINOLINE'>PF6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o8h|2o8h]], [[2ovv|2ovv]], [[3hqw|3hqw]], [[3hqz|3hqz]], [[3hq1|3hq1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PF6:2-({4-[4-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-3-YL]PHENOXY}METHYL)QUINOLINE'>PF6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pde10a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqy OCA], [https://pdbe.org/3hqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hqy RCSB], [https://www.ebi.ac.uk/pdbsum/3hqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqy OCA], [https://pdbe.org/3hqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hqy RCSB], [https://www.ebi.ac.uk/pdbsum/3hqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDE10_RAT PDE10_RAT]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:10583409</ref>
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[https://www.uniprot.org/uniprot/PDE10_RAT PDE10_RAT] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:10583409</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Marr, E S]]
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[[Category: Rattus norvegicus]]
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[[Category: Pandit, J]]
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[[Category: Marr ES]]
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[[Category: Allosteric enzyme]]
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[[Category: Pandit J]]
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[[Category: Alternative splicing]]
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[[Category: Camp]]
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[[Category: Camp-binding]]
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[[Category: Cgmp]]
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[[Category: Cgmp-binding]]
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[[Category: Cytoplasm]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphodiesterase 10a pde 10a pde10 inhibitor]]
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[[Category: Zinc]]
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Current revision

Discovery of novel inhibitors of PDE10A

PDB ID 3hqy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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