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1gsg

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{{STRUCTURE_1gsg| PDB=1gsg | SCENE= }}
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'''STRUCTURE OF E.COLI GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNAGLN AND ATP AT 2.8 ANGSTROMS RESOLUTION'''
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===STRUCTURE OF E.COLI GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNAGLN AND ATP AT 2.8 ANGSTROMS RESOLUTION===
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==Overview==
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The crystal structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) complexed with its cognate glutaminyl transfer RNA (tRNA(Gln] and adenosine triphosphate (ATP) has been derived from a 2.8 angstrom resolution electron density map and the known protein and tRNA sequences. The 63.4-kilodalton monomeric enzyme consists of four domains arranged to give an elongated molecule with an axial ratio greater than 3 to 1. Its interactions with the tRNA extend from the anticodon to the acceptor stem along the entire inside of the L of the tRNA. The complexed tRNA retains the overall conformation of the yeast phenylalanine tRNA (tRNA(Phe] with two major differences: the 3' acceptor strand of tRNA(Gln) makes a hairpin turn toward the inside of the L, with the disruption of the final base pair of the acceptor stem, and the anticodon loop adopts a conformation not seen in any of the previously determined tRNA structures. Specific recognition elements identified so far include (i) enzyme contacts with the 2-amino groups of guanine via the tRNA minor groove in the acceptor stem at G2 and G3; (ii) interactions between the enzyme and the anticodon nucleotides; and (iii) the ability of the nucleotides G73 and U1.A72 of the cognate tRNA to assume a conformation stabilized by the protein at a lower free energy cost than noncognate sequences. The central domain of this synthetase binds ATP, glutamine, and the acceptor end of the tRNA as well as making specific interactions with the acceptor stem.2+t is
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{{ABSTRACT_PUBMED_2479982}}
==About this Structure==
==About this Structure==
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[[Category: Protein/rna]]
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[[Category: Single strand]]
[[Category: Single strand]]
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Revision as of 02:59, 1 July 2008

Image:1gsg.png

Template:STRUCTURE 1gsg

STRUCTURE OF E.COLI GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNAGLN AND ATP AT 2.8 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 2479982

About this Structure

1GSG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution., Rould MA, Perona JJ, Soll D, Steitz TA, Science. 1989 Dec 1;246(4934):1135-42. PMID:2479982

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