1gsm

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[[Image:1gsm.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1gsm| PDB=1gsm | SCENE= }}
{{STRUCTURE_1gsm| PDB=1gsm | SCENE= }}
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'''A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.'''
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===A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.===
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==Overview==
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Mucosal addressin cell-adhesion molecule (MAdCAM-1) is a membrane-bound leukocyte receptor regulating both the passage and retention of leukocytes in mucosal tissues. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1 has previously been reported, confirming their expected immunoglobulin superfamily topology. In this study, a second crystal structure of this fragment is described. Although the overall structure is similar to that previously reported, one edge strand in the amino-terminal domain is instead located on the opposite sheet. This alters the arrangement and conformation of amino acids in this region that have previously been shown to be crucial for ligand binding. MAdCAM-1 is also seen to form dimers within the crystal lattice, raising the possibility that oligomerization may influence the biological role of this adhesion molecule.
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The line below this paragraph, {{ABSTRACT_PUBMED_11807247}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11807247 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11807247}}
==About this Structure==
==About this Structure==
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[[Category: Madcam-1]]
[[Category: Madcam-1]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:57:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:00:37 2008''

Revision as of 03:00, 1 July 2008

Image:1gsm.png

Template:STRUCTURE 1gsm

A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.

Template:ABSTRACT PUBMED 11807247

About this Structure

1GSM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A reassessment of the MAdCAM-1 structure and its role in integrin recognition., Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):233-41. Epub 2002, Jan 24. PMID:11807247

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