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1gto

From Proteopedia

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[[Image:1gto.gif|left|200px]]
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{{STRUCTURE_1gto| PDB=1gto | SCENE= }}
{{STRUCTURE_1gto| PDB=1gto | SCENE= }}
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'''HIGH RESOLUTION STRUCTURE OF A HYPERSTABLE HELICAL BUNDLE PROTEIN MUTANT'''
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===HIGH RESOLUTION STRUCTURE OF A HYPERSTABLE HELICAL BUNDLE PROTEIN MUTANT===
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==Overview==
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A surface turn position in a four-helix bundle protein, Rop, was selected to investigate the role of turns in protein structure and stability. Although all twenty amino acids can be substituted at this position to generate a correctly folded protein, they produce an unusually large range of thermodynamic stabilities. Moreover, the majority of substitutions give rise to proteins with enhanced thermal stability compared to that of the wild type. By introducing the same twenty mutations at this position, but in a simplified context, we were able to deconvolute intrinsic preferences from local environmental effects. The intrinsic preferences can be explained on the basis of preferred backbone dihedral angles, but local environmental context can significantly modify these effects.
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(as it appears on PubMed at http://www.pubmed.gov), where 8548455 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8548455}}
==About this Structure==
==About this Structure==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Turn]]
[[Category: Turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:59:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:03:41 2008''

Revision as of 03:03, 1 July 2008

Image:1gto.png

Template:STRUCTURE 1gto

HIGH RESOLUTION STRUCTURE OF A HYPERSTABLE HELICAL BUNDLE PROTEIN MUTANT

Template:ABSTRACT PUBMED 8548455

About this Structure

1GTO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Amino-acid substitutions in a surface turn modulate protein stability., Predki PF, Agrawal V, Brunger AT, Regan L, Nat Struct Biol. 1996 Jan;3(1):54-8. PMID:8548455

Page seeded by OCA on Tue Jul 1 06:03:41 2008

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