1gtz

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[[Image:1gtz.gif|left|200px]]
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{{STRUCTURE_1gtz| PDB=1gtz | SCENE= }}
{{STRUCTURE_1gtz| PDB=1gtz | SCENE= }}
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'''STRUCTURE OF STREPTOMYCES COELICOLOR TYPE II DEHYDROQUINASE R23A MUTANT IN COMPLEX WITH DEHYDROSHIKIMATE'''
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===STRUCTURE OF STREPTOMYCES COELICOLOR TYPE II DEHYDROQUINASE R23A MUTANT IN COMPLEX WITH DEHYDROSHIKIMATE===
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==Overview==
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The structure of the type II DHQase from Streptomyces coelicolor has been solved and refined to high resolution in complexes with a number of ligands, including dehydroshikimate and a rationally designed transition state analogue, 2,3-anhydro-quinic acid. These structures define the active site of the enzyme and the role of key amino acid residues and provide snap shots of the catalytic cycle. The resolution of the flexible lid domain (residues 21-31) shows that the invariant residues Arg23 and Tyr28 close over the active site cleft. The tyrosine acts as the base in the initial proton abstraction, and evidence is provided that the reaction proceeds via an enol intermediate. The active site of the structure of DHQase in complex with the transition state analog also includes molecules of tartrate and glycerol, which provide a basis for further inhibitor design.
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(as it appears on PubMed at http://www.pubmed.gov), where 11937054 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11937054}}
==About this Structure==
==About this Structure==
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[[Category: Tetrahedral symmetry aromatic amino acid biosynthesis]]
[[Category: Tetrahedral symmetry aromatic amino acid biosynthesis]]
[[Category: Type ii dehydroquinase]]
[[Category: Type ii dehydroquinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:00:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:04:28 2008''

Revision as of 03:04, 1 July 2008

Image:1gtz.png

Template:STRUCTURE 1gtz

STRUCTURE OF STREPTOMYCES COELICOLOR TYPE II DEHYDROQUINASE R23A MUTANT IN COMPLEX WITH DEHYDROSHIKIMATE

Template:ABSTRACT PUBMED 11937054

About this Structure

1GTZ is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor., Roszak AW, Robinson DA, Krell T, Hunter IS, Fredrickson M, Abell C, Coggins JR, Lapthorn AJ, Structure. 2002 Apr;10(4):493-503. PMID:11937054

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