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| - | [[Folylpolyglutamate synthetase]] (FPGS) attaches gamma-glutamate units to various forms of folate (vitamin B9). In eukaryotic organisms, polyglutamylation keeps folate in the compartment, while folate lacking it can travel to other compartments. To be effecitive, antifolates (competitive inhibitors whose structure is similar to tetrahydrofolate) have to undergo polyglutamylation as well. Thus, defects in FPGS have consequences for the one-carbon metabolism relying on availability of folate as well as treatment of cancer relying on antifolates. | + | see [[Folylpolyglutamate synthase]] |
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| - | == Reaction ==
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| - | [[Image:Tetrahydrofolate synthase hydrolase.PNG|600px]]
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| - | == FPGS in different organisms ==
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| - | EC numbers: 6.3.2.12 (DHF synthase) and 6.3.2.17 (poly)
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| - | Precursor:
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| - | [[Image:Dihydropteroate.png|thumb]]
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| - | Reaction:
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| - | [[Image:FolC_reaction.png|thumb]]
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| - | Compartments<ref>DOI:10.1093/oxfordjournals.annonc.a059353</ref>
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| - | Rheumatoid arthritis<ref>DOI:10.1093/rheumatology/keaa428</ref>
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| - | Substrate binding and mechanism ([[1jbv]] and [[1jbw]]): <ref>DOI:10.1006/jmbi.2001.4815</ref>
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| - | Primary citation of [[1w78]] <ref>PMID:15705579</ref>
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| - | Synthesis of folate<ref>DOI:10.1186/1471-2164-8-245</ref>
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| - | ==Your Heading Here (maybe something like 'Structure')==
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| - | <StructureSection load='1W78' size='340' side='right' caption='FolC' scene=''>
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| - | </StructureSection>
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| - | == References ==
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| - | <references/>
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Current revision
see Folylpolyglutamate synthase
