7u4q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Synaptotagmin-1 C2A Y181F Ca2+ bound== | |
| - | + | <StructureSection load='7u4q' size='340' side='right'caption='[[7u4q]], [[Resolution|resolution]] 1.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7u4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4q OCA], [https://pdbe.org/7u4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4q RCSB], [https://www.ebi.ac.uk/pdbsum/7u4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4q ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Fuson | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dominguez MJ]] | ||
| + | [[Category: Fuson KL]] | ||
| + | [[Category: Karmakar S]] | ||
| + | [[Category: Sutton RB]] | ||
Revision as of 09:47, 15 March 2023
Human Synaptotagmin-1 C2A Y181F Ca2+ bound
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