This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1gux

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1gux.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1gux.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1gux| PDB=1gux | SCENE= }}
{{STRUCTURE_1gux| PDB=1gux | SCENE= }}
-
'''RB POCKET BOUND TO E7 LXCXE MOTIF'''
+
===RB POCKET BOUND TO E7 LXCXE MOTIF===
-
==Overview==
+
<!--
-
The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9495340}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Retinoblastoma]]
[[Category: Retinoblastoma]]
[[Category: Tumor suppressor protein]]
[[Category: Tumor suppressor protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:02:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:07:27 2008''

Revision as of 03:07, 1 July 2008


PDB ID 1gux

Drag the structure with the mouse to rotate
1gux, resolution 1.85Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



RB POCKET BOUND TO E7 LXCXE MOTIF

Template:ABSTRACT PUBMED 9495340

About this Structure

1GUX is a Protein complex structure of sequences from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.

Reference

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7., Lee JO, Russo AA, Pavletich NP, Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340

Page seeded by OCA on Tue Jul 1 06:07:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gux"
Personal tools