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4qgn

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Current revision (06:50, 9 August 2023) (edit) (undo)
 
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<StructureSection load='4qgn' size='340' side='right'caption='[[4qgn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
<StructureSection load='4qgn' size='340' side='right'caption='[[4qgn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qgn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QGN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qgn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QGN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADI1, HMFT1638, MTCBP1, NP_060739 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acireductone_dioxygenase_(Fe(2+)-requiring) Acireductone dioxygenase (Fe(2+)-requiring)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.54 1.13.11.54] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qgn OCA], [https://pdbe.org/4qgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qgn RCSB], [https://www.ebi.ac.uk/pdbsum/4qgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qgn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qgn OCA], [https://pdbe.org/4qgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qgn RCSB], [https://www.ebi.ac.uk/pdbsum/4qgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qgn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MTND_HUMAN MTND_HUMAN]] Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.[HAMAP-Rule:MF_03154]<ref>PMID:11602742</ref> <ref>PMID:15938715</ref>
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[https://www.uniprot.org/uniprot/MTND_HUMAN MTND_HUMAN] Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.[HAMAP-Rule:MF_03154]<ref>PMID:11602742</ref> <ref>PMID:15938715</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Borowski, T]]
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[[Category: Borowski T]]
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[[Category: Chruszcz, M]]
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[[Category: Chruszcz M]]
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[[Category: Milaczewska, A M]]
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[[Category: Milaczewska AM]]
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[[Category: Minor, W]]
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[[Category: Minor W]]
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[[Category: Niedzialkowska, E]]
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[[Category: Niedzialkowska E]]
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[[Category: Petkowski, J J]]
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[[Category: Petkowski JJ]]
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[[Category: Iron binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rmlc-like cupin]]
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Current revision

Human acireductone dioxygenase with iron ion and L-methionine in active center

PDB ID 4qgn

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