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1gve

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{{STRUCTURE_1gve| PDB=1gve | SCENE= }}
{{STRUCTURE_1gve| PDB=1gve | SCENE= }}
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'''AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER'''
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===AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER===
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==Overview==
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The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has been solved to 1.38-A resolution. Although it shares a similar alpha/beta-barrel structure with other members of the aldo-keto reductase superfamily, AKR7A1 is the first dimeric member to be crystallized. The crystal structure also reveals details of the ternary complex as one subunit of the dimer contains NADP(+) and the inhibitor citrate. Although the underlying catalytic mechanism appears similar to other aldo-keto reductases, the substrate-binding pocket contains several charged amino acids (Arg-231 and Arg-327) that distinguish it from previously characterized aldo-keto reductases with respect to size and charge. These differences account for the substrate specificity for 4-carbon acid-aldehydes such as succinic semialdehyde and 2-carboxybenzaldehyde as well as for the idiosyncratic substrate aflatoxin B(1) dialdehyde of this subfamily of enzymes. Structural differences between the AKR7A1 ternary complex and apoenzyme reveal a significant hinged movement of the enzyme involving not only the loops of the structure but also parts of the alpha/beta-barrel most intimately involved in cofactor binding.
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{{ABSTRACT_PUBMED_11839745}}
==About this Structure==
==About this Structure==
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[[Category: Aldo-keto reductase]]
[[Category: Aldo-keto reductase]]
[[Category: Succinic semialdehyde oxidoreductase]]
[[Category: Succinic semialdehyde oxidoreductase]]
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Revision as of 03:08, 1 July 2008

Image:1gve.png

Template:STRUCTURE 1gve

AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER

Template:ABSTRACT PUBMED 11839745

About this Structure

1GVE is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily., Kozma E, Brown E, Ellis EM, Lapthorn AJ, J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745

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