7m6u

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Current revision (16:06, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7m6u' size='340' side='right'caption='[[7m6u]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='7m6u' size='340' side='right'caption='[[7m6u]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7m6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pses6 Pses6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M6U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7m6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._RS-16 Pseudomonas sp. RS-16] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M6U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cg2|1cg2]], [[6xj5|6xj5]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cpg2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=312 PSES6])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate_carboxypeptidase Glutamate carboxypeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.11 3.4.17.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m6u OCA], [https://pdbe.org/7m6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m6u RCSB], [https://www.ebi.ac.uk/pdbsum/7m6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m6u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m6u OCA], [https://pdbe.org/7m6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m6u RCSB], [https://www.ebi.ac.uk/pdbsum/7m6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m6u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CBPG_PSES6 CBPG_PSES6]] Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity.
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[https://www.uniprot.org/uniprot/CBPG_PSES6 CBPG_PSES6] Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutamate carboxypeptidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pses6]]
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[[Category: Pseudomonas sp. RS-16]]
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[[Category: Khare, S D]]
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[[Category: Synthetic construct]]
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[[Category: Yachnin, B J]]
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[[Category: Khare SD]]
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[[Category: Circular permutation]]
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[[Category: Yachnin BJ]]
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[[Category: Directed enzyme-prodrug therapy]]
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[[Category: Enzyme design]]
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[[Category: Hydrolase]]
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[[Category: Methotrexate]]
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[[Category: Pro-enzyme]]
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Current revision

Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase G2

PDB ID 7m6u

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