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7u8t

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Current revision (09:38, 14 February 2024) (edit) (undo)
 
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<StructureSection load='7u8t' size='340' side='right'caption='[[7u8t]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='7u8t' size='340' side='right'caption='[[7u8t]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7u8t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U8T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7u8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U8T FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u8t OCA], [https://pdbe.org/7u8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u8t RCSB], [https://www.ebi.ac.uk/pdbsum/7u8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u8t ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u8t OCA], [https://pdbe.org/7u8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u8t RCSB], [https://www.ebi.ac.uk/pdbsum/7u8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u8t ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G0S0T5_CHATD G0S0T5_CHATD] [https://www.uniprot.org/uniprot/VPS13_CHATD VPS13_CHATD] Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids, including phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), and phosphatidylserine (PS) (PubMed:30093493). May play a role in mitochondrial lipid homeostasis, Golgi vesicle transport, reticulophagy, actin cytoskeleton organization and formation of the prospore membrane (By similarity).[UniProtKB:Q07878]<ref>PMID:30093493</ref>
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VPS13 proteins are proposed to function at contact sites between organelles as bridges for lipids to move directionally and in bulk between organellar membranes. VPS13s are anchored between membranes via interactions with receptors, including both peripheral and integral membrane proteins. Here we present the crystal structure of VPS13s adaptor binding domain (VAB) complexed with a Pro-X-Pro peptide recognition motif present in one such receptor, the integral membrane protein Mcp1p, and show biochemically that other Pro-X-Pro motifs bind the VAB in the same site. We further demonstrate that Mcp1p and another integral membrane protein that interacts directly with human VPS13A, XK, are scramblases. This finding supports an emerging paradigm of a partnership between bulk lipid transport proteins and scramblases. Scramblases can re-equilibrate lipids between membrane leaflets as lipids are removed from or inserted into the cytosolic leaflet of donor and acceptor organelles, respectively, in the course of protein-mediated transport.
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Structural and biochemical insights into lipid transport by VPS13 proteins.,Adlakha J, Hong Z, Li P, Reinisch KM J Cell Biol. 2022 Jun 6;221(5). pii: 213104. doi: 10.1083/jcb.202202030. Epub, 2022 Mar 31. PMID:35357422<ref>PMID:35357422</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7u8t" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chaetomium thermophilum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Adlakha, J]]
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[[Category: Adlakha J]]
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[[Category: Reinisch, K M]]
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[[Category: Reinisch KM]]
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[[Category: Adaptor binding domain]]
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[[Category: Lipid transport]]
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Current revision

Vps13 adaptor binding domain in complex with Mcp1 PxP motif peptide

PDB ID 7u8t

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