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2x05

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Current revision (10:20, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2x05' size='340' side='right'caption='[[2x05]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2x05' size='340' side='right'caption='[[2x05]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x05]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptomyces_orientalis"_pittenger_and_brigham_1956 "streptomyces orientalis" pittenger and brigham 1956]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X05 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x05]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_orientalis Amycolatopsis orientalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X05 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=X05:AMINO-CASTANOSPERMINE'>X05</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vzr|2vzr]], [[2vzu|2vzu]], [[2vzs|2vzs]], [[2vzt|2vzt]], [[2vzo|2vzo]], [[2vzq|2vzq]], [[2vzp|2vzp]], [[2vzv|2vzv]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=X05:AMINO-CASTANOSPERMINE'>X05</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-1,4-beta-D-glucosaminidase Exo-1,4-beta-D-glucosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.165 3.2.1.165] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x05 OCA], [https://pdbe.org/2x05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x05 RCSB], [https://www.ebi.ac.uk/pdbsum/2x05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x05 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x05 OCA], [https://pdbe.org/2x05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x05 RCSB], [https://www.ebi.ac.uk/pdbsum/2x05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x05 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EBDG_AMYOR EBDG_AMYOR] Hydrolyzes chitosan and chitooligosaccharides with retention of anomeric configuration. Has maximum activity on chitotetraose, chitopentaose and their corresponding alcohols, with a slight decrease in the rate of hydrolysis on longer chains. Has no activity against beta-D-glucopyranoside, beta-D-xylopyranoside, beta-D-mannoside, beta-D-glucuronide, beta-D-galactoside, beta-D-N-acetylgalactosamide, beta-D-N-acetylglucosaminide and alpha-D-N-acetylglucosaminide.<ref>PMID:16316314</ref> <ref>PMID:2351651</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptomyces orientalis pittenger and brigham 1956]]
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[[Category: Amycolatopsis orientalis]]
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[[Category: Exo-1,4-beta-D-glucosaminidase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boraston, A B]]
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[[Category: Boraston AB]]
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[[Category: Brzezinski, R]]
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[[Category: Brzezinski R]]
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[[Category: Ghinet, M G]]
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[[Category: Ghinet MG]]
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[[Category: Pluvinage, B]]
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[[Category: Pluvinage B]]
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[[Category: Stubbs, K A]]
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[[Category: Stubbs KA]]
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[[Category: Csxa]]
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[[Category: Exo-beta-d-glucosaminidase]]
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[[Category: Gh2]]
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[[Category: Glycosidase]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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Current revision

Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine- configured castanospermine and an amino-australine analogue

PDB ID 2x05

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