2x6l
From Proteopedia
(Difference between revisions)
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<StructureSection load='2x6l' size='340' side='right'caption='[[2x6l]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2x6l' size='340' side='right'caption='[[2x6l]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x6l]] is a 5 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kkh 3kkh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X6L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2x6l]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kkh 3kkh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X6L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.602Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x6l OCA], [https://pdbe.org/2x6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x6l RCSB], [https://www.ebi.ac.uk/pdbsum/2x6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x6l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x6l OCA], [https://pdbe.org/2x6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x6l RCSB], [https://www.ebi.ac.uk/pdbsum/2x6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x6l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CCL4_HUMAN CCL4_HUMAN] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Guo | + | [[Category: Guo Q]] |
| - | [[Category: Ren | + | [[Category: Ren M]] |
| - | [[Category: Tang | + | [[Category: Tang W]] |
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Current revision
X-ray Structure of Macrophage Inflammatory Protein-1 beta
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Categories: Homo sapiens | Large Structures | Guo Q | Ren M | Tang W
