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2xcr

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Current revision (10:24, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2xcr' size='340' side='right'caption='[[2xcr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='2xcr' size='340' side='right'caption='[[2xcr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene>, <scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xcs|2xcs]], [[2xct|2xct]], [[2xco|2xco]], [[2xcq|2xcq]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [https://pdbe.org/2xcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [https://www.ebi.ac.uk/pdbsum/2xcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [https://pdbe.org/2xcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [https://www.ebi.ac.uk/pdbsum/2xcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
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[https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staan]]
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[[Category: Staphylococcus aureus]]
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[[Category: Bax, B D]]
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[[Category: Synthetic construct]]
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[[Category: Brown, K K]]
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[[Category: Bax BD]]
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[[Category: Chan, P F]]
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[[Category: Brown KK]]
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[[Category: Eggleston, D S]]
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[[Category: Chan PF]]
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[[Category: Fosberry, A]]
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[[Category: Eggleston DS]]
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[[Category: Gentry, D R]]
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[[Category: Fosberry A]]
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[[Category: Giordano, I]]
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[[Category: Gentry DR]]
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[[Category: Gorrec, F]]
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[[Category: Giordano I]]
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[[Category: Gwynn, M N]]
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[[Category: Gorrec F]]
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[[Category: Hann, M M]]
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[[Category: Gwynn MN]]
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[[Category: Hennessy, A]]
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[[Category: Hann MM]]
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[[Category: Hibbs, M]]
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[[Category: Hennessy A]]
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[[Category: Huang, J]]
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[[Category: Hibbs M]]
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[[Category: Jones, E]]
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[[Category: Huang J]]
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[[Category: Jones, J]]
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[[Category: Jones E]]
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[[Category: Lewis, C J]]
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[[Category: Jones J]]
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[[Category: May, E W]]
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[[Category: Lewis CJ]]
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[[Category: Pearson, N D]]
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[[Category: May EW]]
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[[Category: Shen, C]]
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[[Category: Pearson ND]]
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[[Category: Shillings, A]]
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[[Category: Shen C]]
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[[Category: Singh, O]]
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[[Category: Shillings A]]
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[[Category: Spitzfaden, C]]
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[[Category: Singh O]]
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[[Category: Theobald, A F]]
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[[Category: Spitzfaden C]]
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[[Category: Wohlkonig, A]]
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[[Category: Theobald AF]]
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[[Category: Isomerase]]
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[[Category: Wohlkonig A]]

Current revision

The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA

PDB ID 2xcr

Drag the structure with the mouse to rotate

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