2xdw

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<StructureSection load='2xdw' size='340' side='right'caption='[[2xdw]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='2xdw' size='340' side='right'caption='[[2xdw]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xdw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xdw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene>, <scene name='pdbligand=YCP:(2S)-PIPERIDINE-2-CARBOXYLIC+ACID'>YCP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=YCP:(2S)-PIPERIDINE-2-CARBOXYLIC+ACID'>YCP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h2x|1h2x]], [[1qfm|1qfm]], [[1vz2|1vz2]], [[1h2y|1h2y]], [[1o6g|1o6g]], [[1vz3|1vz3]], [[1e5t|1e5t]], [[1o6f|1o6f]], [[1uoq|1uoq]], [[1e8m|1e8m]], [[1e8n|1e8n]], [[1h2z|1h2z]], [[1uop|1uop]], [[1h2w|1h2w]], [[1uoo|1uoo]], [[1qfs|1qfs]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdw OCA], [https://pdbe.org/2xdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdw RCSB], [https://www.ebi.ac.uk/pdbsum/2xdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdw OCA], [https://pdbe.org/2xdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdw RCSB], [https://www.ebi.ac.uk/pdbsum/2xdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
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[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pig]]
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[[Category: Sus scrofa]]
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[[Category: Prolyl oligopeptidase]]
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[[Category: Synthetic construct]]
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[[Category: Fulop, V]]
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[[Category: Fulop V]]
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[[Category: Racys, D T]]
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[[Category: Racys DT]]
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[[Category: Rea, D]]
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[[Category: Rea D]]
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[[Category: Wills, M]]
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[[Category: Wills M]]
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[[Category: Alpha/beta-hydrolase]]
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[[Category: Amnesia]]
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[[Category: Beta-propeller]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Revision as of 10:29, 20 December 2023

Inhibition of Prolyl Oligopeptidase with a Synthetic Unnatural Dipeptide

PDB ID 2xdw

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