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2xg5

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Current revision (10:30, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2xg5' size='340' side='right'caption='[[2xg5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2xg5' size='340' side='right'caption='[[2xg5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xg5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xg5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EC2:(2R,3R)-8-CYCLOPROPYL-7-(NAPHTHALEN-1-YLMETHYL)-5-OXO-2-PHENYL-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC+ACID'>EC2</scene>, <scene name='pdbligand=EC5:(2R)-2-[5-CYCLOPROPYL-6-(HYDROXYSULFANYL)-4-(NAPHTHALEN-1-YLMETHYL)-2-OXOPYRIDIN-1(2H)-YL]-3-PHENYLPROPANOIC+ACID'>EC5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j2z|2j2z]], [[1qpp|1qpp]], [[1qpx|1qpx]], [[2wmp|2wmp]], [[2xg4|2xg4]], [[3dpa|3dpa]], [[1pdk|1pdk]], [[1n0l|1n0l]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EC2:(2R,3R)-8-CYCLOPROPYL-7-(NAPHTHALEN-1-YLMETHYL)-5-OXO-2-PHENYL-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC+ACID'>EC2</scene>, <scene name='pdbligand=EC5:(2R)-2-[5-CYCLOPROPYL-6-(HYDROXYSULFANYL)-4-(NAPHTHALEN-1-YLMETHYL)-2-OXOPYRIDIN-1(2H)-YL]-3-PHENYLPROPANOIC+ACID'>EC5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg5 OCA], [https://pdbe.org/2xg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg5 OCA], [https://pdbe.org/2xg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PAPD_ECOLX PAPD_ECOLX]] Binds and caps interactive surfaces on pilus subunits to prevent them from participating in non-productive interactions. Facilitates the import of subunits into the periplasm. May facilitate subunit folding. Chaperone-subunit complexes are then targeted to the PapC outer membrane usher where the chaperone must uncap from the subunits. [[https://www.uniprot.org/uniprot/PAPH_ECOLX PAPH_ECOLX]] Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. PapH seems to anchor the pilus to the bacterial cell. In addition the stoichiometric relationship between PapH and PapA determines the pilus length.
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[https://www.uniprot.org/uniprot/PAPD_ECOLX PAPD_ECOLX] Binds and caps interactive surfaces on pilus subunits to prevent them from participating in non-productive interactions. Facilitates the import of subunits into the periplasm. May facilitate subunit folding. Chaperone-subunit complexes are then targeted to the PapC outer membrane usher where the chaperone must uncap from the subunits.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Almqvist, F]]
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[[Category: Almqvist F]]
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[[Category: Buelens, F]]
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[[Category: Buelens F]]
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[[Category: Chorell, E]]
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[[Category: Chorell E]]
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[[Category: Edvinsson, S]]
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[[Category: Edvinsson S]]
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[[Category: Hultgren, S J]]
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[[Category: Hultgren SJ]]
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[[Category: Phan, G]]
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[[Category: Phan G]]
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[[Category: Pinkner, J S]]
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[[Category: Pinkner JS]]
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[[Category: Remaut, H]]
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[[Category: Remaut H]]
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[[Category: Waksman, G]]
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[[Category: Waksman G]]
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[[Category: Chaperone]]
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[[Category: Chaperone-surface active protein complex]]
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Current revision

E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 5d

PDB ID 2xg5

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