3i3c

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Current revision (10:03, 21 February 2024) (edit) (undo)
 
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<StructureSection load='3i3c' size='340' side='right'caption='[[3i3c]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
<StructureSection load='3i3c' size='340' side='right'caption='[[3i3c]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3i3c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I3C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3i3c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I3C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX5, HP1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3c OCA], [https://pdbe.org/3i3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i3c RCSB], [https://www.ebi.ac.uk/pdbsum/3i3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3c OCA], [https://pdbe.org/3i3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i3c RCSB], [https://www.ebi.ac.uk/pdbsum/3i3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CBX5_HUMAN CBX5_HUMAN]] Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<ref>PMID:19783980</ref>
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[https://www.uniprot.org/uniprot/CBX5_HUMAN CBX5_HUMAN] Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<ref>PMID:19783980</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amaya, M F]]
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[[Category: Amaya MF]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Kozieradzki, I]]
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[[Category: Kozieradzki I]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Li, Z]]
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[[Category: Li Z]]
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[[Category: Min, J]]
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[[Category: Min J]]
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[[Category: Ouyang, H]]
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[[Category: Ouyang H]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Cbx5]]
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[[Category: Centromere]]
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[[Category: Chromo shadow domain]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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Current revision

Crystal Structural of CBX5 Chromo Shadow Domain

PDB ID 3i3c

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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