3i59

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<StructureSection load='3i59' size='340' side='right'caption='[[3i59]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='3i59' size='340' side='right'caption='[[3i59]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3i59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I59 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3i59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I59 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6R:(2R)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6R</scene>, <scene name='pdbligand=N6S:(2S)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6S</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=N6R:(2R)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6R</scene>, <scene name='pdbligand=N6S:(2S)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6S</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i54|3i54]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3777, Rv3676 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i59 OCA], [https://pdbe.org/3i59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i59 RCSB], [https://www.ebi.ac.uk/pdbsum/3i59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i59 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i59 OCA], [https://pdbe.org/3i59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i59 RCSB], [https://www.ebi.ac.uk/pdbsum/3i59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i59 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CRP_MYCTO CRP_MYCTO]] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Activates expression of whiB1.<ref>PMID:16946269</ref>
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[https://www.uniprot.org/uniprot/CRPL_MYCTU CRPL_MYCTU] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled.<ref>PMID:15882420</ref> <ref>PMID:20028978</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bruning, J B]]
 
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[[Category: Palaninathan, S K]]
 
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[[Category: Reddy, M C]]
 
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[[Category: Sacchettini, J C]]
 
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[[Category: Smith, D]]
 
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[[Category: Structural genomic]]
 
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[[Category: Thurman, C]]
 
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[[Category: Allosteric mechanism]]
 
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[[Category: Camp receptor protein]]
 
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[[Category: Crp]]
 
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[[Category: Dna binding]]
 
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[[Category: Dna binding protein]]
 
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[[Category: Dna-binding]]
 
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[[Category: Inhibition]]
 
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: N6-camp]]
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[[Category: Bruning JB]]
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[[Category: Tbsgc]]
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[[Category: Palaninathan SK]]
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[[Category: Transcription]]
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[[Category: Reddy MC]]
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[[Category: Transcription regulation]]
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[[Category: Sacchettini JC]]
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[[Category: Smith D]]
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[[Category: Thurman C]]

Revision as of 07:37, 6 September 2023

Crystal structure of MtbCRP in complex with N6-cAMP

PDB ID 3i59

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