1efx
From Proteopedia
(New page: 200px<br /> <applet load="1efx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1efx, resolution 3.0Å" /> '''STRUCTURE OF A COMPL...) |
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caption="1efx, resolution 3.0Å" /> | caption="1efx, resolution 3.0Å" /> | ||
'''STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3'''<br /> | '''STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1EFX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1EFX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: receptor/mhc complex]] | [[Category: receptor/mhc complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:43:04 2008'' |
Revision as of 13:43, 15 February 2008
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STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3
Contents |
Overview
Target cell lysis is regulated by natural killer (NK) cell receptors that, recognize class I MHC molecules. Here we report the crystal structure of, the human immunoglobulin-like NK cell receptor KIR2DL2 in complex with its, class I ligand HLA-Cw3 and peptide. KIR binds in a nearly orthogonal, orientation across the alpha1 and alpha2 helices of Cw3 and directly, contacts positions 7 and 8 of the peptide. No significant conformational, changes in KIR occur on complex formation. The receptor footprint on HLA, overlaps with but is distinct from that of the T-cell receptor. Charge, complementarity dominates the KIR/HLA interface and mutations that disrupt, interface salt bridges substantially diminish binding. Most contacts in, the complex are between KIR and conserved HLA-C residues, but a hydrogen, bond between Lys 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype, specificity. KIR contact requires position 8 of the peptide to be a, residue smaller than valine. A second KIR/HLA interface produced an, ordered receptor-ligand aggregation in the crystal which may resemble, receptor clustering during immune synapse formation.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1EFX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand., Boyington JC, Motyka SA, Schuck P, Brooks AG, Sun PD, Nature. 2000 Jun 1;405(6786):537-43. PMID:10850706
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