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7unk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex== | |
| - | + | <StructureSection load='7unk' size='340' side='right'caption='[[7unk]], [[Resolution|resolution]] 3.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7unk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UNK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7unk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7unk OCA], [https://pdbe.org/7unk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7unk RCSB], [https://www.ebi.ac.uk/pdbsum/7unk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7unk ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Bernardes NE]] | ||
| + | [[Category: Chen Z]] | ||
| + | [[Category: Chook YM]] | ||
| + | [[Category: Fung HYJ]] | ||
| + | [[Category: Li Y]] | ||
Current revision
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
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