7wve

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7wve is ON HOLD until Paper Publication
+
==CT-mut (D523K,D524K,E527K) TLR3-poly(I:C) complex==
-
 
+
<StructureSection load='7wve' size='340' side='right'caption='[[7wve]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7wve]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WVE FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wve OCA], [https://pdbe.org/7wve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wve RCSB], [https://www.ebi.ac.uk/pdbsum/7wve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wve ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TLR3_HUMAN TLR3_HUMAN] Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:[https://omim.org/entry/613002 613002]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.<ref>PMID:17872438</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TLR3_HUMAN TLR3_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:16144834</ref> <ref>PMID:16858407</ref> <ref>PMID:16720699</ref> <ref>PMID:17178723</ref> <ref>PMID:18172197</ref> <ref>PMID:16043704</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Synthetic construct]]
 +
[[Category: Han GM]]
 +
[[Category: Jang YH]]
 +
[[Category: Lee GY]]
 +
[[Category: Lee JO]]
 +
[[Category: Lim CS]]

Revision as of 20:07, 16 November 2022

CT-mut (D523K,D524K,E527K) TLR3-poly(I:C) complex

PDB ID 7wve

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7wve"
Personal tools