7o5y
From Proteopedia
(Difference between revisions)
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==PilA minor pilin of Streptococcus sanguinis type IV pili== | ==PilA minor pilin of Streptococcus sanguinis type IV pili== | ||
| - | <StructureSection load='7o5y' size='340' side='right'caption='[[7o5y]]' scene=''> | + | <StructureSection load='7o5y' size='340' side='right'caption='[[7o5y]], [[Resolution|resolution]] 1.77Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O5Y FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7o5y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sanguinis Streptococcus sanguinis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O5Y FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o5y OCA], [https://pdbe.org/7o5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o5y RCSB], [https://www.ebi.ac.uk/pdbsum/7o5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o5y ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o5y OCA], [https://pdbe.org/7o5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o5y RCSB], [https://www.ebi.ac.uk/pdbsum/7o5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o5y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0B7GNW3_STRSA A0A0B7GNW3_STRSA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Type 4 filaments (T4F)-of which type 4 pili (T4P) are the archetype-are a superfamily of nanomachines nearly ubiquitous in prokaryotes. T4F are polymers of one major pilin, which also contain minor pilins whose roles are often poorly understood. Here, we complete the structure/function analysis of the full set of T4P pilins in the opportunistic bacterial pathogen Streptococcus sanguinis. We determined the structure of the minor pilin PilA, which is unexpectedly similar to one of the subunits of a tip-located complex of four minor pilins, widely conserved in T4F. We found that PilA interacts and dramatically stabilizes the minor pilin PilC. We determined the structure of PilC, showing that it is a modular pilin with a lectin module binding a subset of glycans prevalent in the human glycome, the host of S. sanguinis. Altogether, our findings support a model whereby the minor pilins in S. sanguinis T4P form a tip-located complex promoting adhesion to various host receptors. This has general implications for T4F. | ||
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| + | Characterization of a glycan-binding complex of minor pilins completes the analysis of Streptococcus sanguinis type 4 pili subunits.,Shahin M, Sheppard D, Raynaud C, Berry JL, Gurung I, Silva LM, Feizi T, Liu Y, Pelicic V Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2216237120. doi: , 10.1073/pnas.2216237120. Epub 2023 Jan 10. PMID:36626560<ref>PMID:36626560</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7o5y" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Streptococcus sanguinis]] | ||
[[Category: Berry JB]] | [[Category: Berry JB]] | ||
[[Category: Pelicic V]] | [[Category: Pelicic V]] | ||
[[Category: Sheppard D]] | [[Category: Sheppard D]] | ||
Current revision
PilA minor pilin of Streptococcus sanguinis type IV pili
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