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3ig0

From Proteopedia

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Current revision (15:57, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3ig0' size='340' side='right'caption='[[3ig0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3ig0' size='340' side='right'caption='[[3ig0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ig0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IG0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ig0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IG0 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zjt|2zjt]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB, MT0005, MTCY10H4.03, Rv0005 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ig0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ig0 OCA], [https://pdbe.org/3ig0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ig0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ig0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ig0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ig0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ig0 OCA], [https://pdbe.org/3ig0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ig0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ig0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ig0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GYRB_MYCTU GYRB_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
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[https://www.uniprot.org/uniprot/GYRB_MYCTU GYRB_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Aubry, A]]
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[[Category: Aubry A]]
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[[Category: Delarue, M]]
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[[Category: Delarue M]]
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[[Category: Mayer, C]]
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[[Category: Mayer C]]
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[[Category: Piton, J]]
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[[Category: Piton J]]
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[[Category: Atp-binding]]
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[[Category: Dna binding site]]
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[[Category: Dna gyrase]]
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[[Category: Gyrb]]
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[[Category: Isomerase]]
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[[Category: Nucleotide-binding]]
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[[Category: Quinolone binding site]]
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[[Category: Topoisomerase]]
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[[Category: Toprim]]
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[[Category: Tuberculosis]]
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[[Category: Type ii topoisomerase]]
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Current revision

crystal structure of the second part of the Mycobacterium tuberculosis DNA gyrase reaction core: the TOPRIM domain at 2.1 A resolution

PDB ID 3ig0

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