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3ihy
From Proteopedia
(Difference between revisions)
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<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Arrowsmith CH]] | |
| - | [[Category: Arrowsmith | + | [[Category: Berglund H]] |
| - | + | [[Category: Bountra C]] | |
| - | [[Category: Berglund | + | [[Category: Collins R]] |
| - | [[Category: Bountra | + | [[Category: Edwards AM]] |
| - | [[Category: Collins | + | [[Category: Flodin S]] |
| - | [[Category: Edwards | + | [[Category: Flores A]] |
| - | [[Category: Flodin | + | [[Category: Graslund S]] |
| - | [[Category: Flores | + | [[Category: Hammarstrom M]] |
| - | [[Category: Graslund | + | [[Category: Johansson A]] |
| - | [[Category: Hammarstrom | + | [[Category: Johansson I]] |
| - | [[Category: Johansson | + | [[Category: Karlberg T]] |
| - | [[Category: Johansson | + | [[Category: Kotenyova T]] |
| - | [[Category: Karlberg | + | [[Category: Kotzsch A]] |
| - | [[Category: Kotenyova | + | [[Category: Kragh Nielsen T]] |
| - | [[Category: Kotzsch | + | [[Category: Moche M]] |
| - | [[Category: | + | [[Category: Nordlund P]] |
| - | [[Category: | + | [[Category: Nyman T]] |
| - | [[Category: Nordlund | + | [[Category: Persson C]] |
| - | [[Category: Nyman | + | [[Category: Roos AK]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | [[Category: Roos | + | [[Category: Schueler H]] |
| - | + | [[Category: Schutz P]] | |
| - | [[Category: Sagemark | + | [[Category: Siponen MI]] |
| - | [[Category: Schueler | + | [[Category: Thorsell AG]] |
| - | [[Category: Schutz | + | [[Category: Tresaugues L]] |
| - | [[Category: Siponen | + | [[Category: Van Den Berg S]] |
| - | [[Category: Thorsell | + | [[Category: Weigelt J]] |
| - | [[Category: Tresaugues | + | [[Category: Welin M]] |
| - | [[Category: | + | [[Category: Wisniewska M]] |
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Current revision
Human PIK3C3 crystal structure
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Karlberg T | Kotenyova T | Kotzsch A | Kragh Nielsen T | Moche M | Nordlund P | Nyman T | Persson C | Roos AK | Sagemark J | Schueler H | Schutz P | Siponen MI | Thorsell AG | Tresaugues L | Van Den Berg S | Weigelt J | Welin M | Wisniewska M
