3ilw

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Current revision (07:53, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3ilw' size='340' side='right'caption='[[3ilw]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3ilw' size='340' side='right'caption='[[3ilw]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ilw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ILW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ILW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ilw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ILW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ILW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.603&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrA, MT0006, MTCY10H4.04, Rv0006 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ilw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ilw OCA], [https://pdbe.org/3ilw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ilw RCSB], [https://www.ebi.ac.uk/pdbsum/3ilw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ilw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ilw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ilw OCA], [https://pdbe.org/3ilw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ilw RCSB], [https://www.ebi.ac.uk/pdbsum/3ilw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ilw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
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[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Berger, J M]]
 
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[[Category: Schoeffler, A J]]
 
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[[Category: Structural genomic]]
 
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[[Category: Tretter, E M]]
 
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[[Category: Weisfield, S R]]
 
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[[Category: Antibiotic resistance]]
 
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[[Category: Atp-binding]]
 
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[[Category: Breakage-reunion domain]]
 
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[[Category: Dna topology]]
 
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[[Category: Dna-binding]]
 
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[[Category: Gyrase]]
 
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[[Category: Isomerase]]
 
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Nucleotide-binding]]
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[[Category: Berger JM]]
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[[Category: Tbsgc]]
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[[Category: Schoeffler AJ]]
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[[Category: Topoisomerase]]
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[[Category: Tretter EM]]
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[[Category: Weisfield SR]]

Current revision

Structure of DNA gyrase subunit A N-terminal domain

PDB ID 3ilw

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