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3inw

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Current revision (07:54, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3inw' size='340' side='right'caption='[[3inw]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3inw' size='340' side='right'caption='[[3inw]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3inw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3inw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZB:(5E,9E,11E)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3inx|3inx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZB:(5E,9E,11E)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZB</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inw OCA], [https://pdbe.org/3inw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inw RCSB], [https://www.ebi.ac.uk/pdbsum/3inw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inw OCA], [https://pdbe.org/3inw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inw RCSB], [https://www.ebi.ac.uk/pdbsum/3inw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-chaperonin molecular chaperone ATPase]]
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[[Category: Korndoerfer IP]]
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[[Category: Korndoerfer, I P]]
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[[Category: 2-layer sandwich]]
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[[Category: Alpha beta]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Pochonin]]
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[[Category: Pochoxime]]
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[[Category: Radicicol]]
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[[Category: Ral]]
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[[Category: Sp]]
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[[Category: Stress response]]
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Current revision

HSP90 N-TERMINAL DOMAIN with pochoxime A

PDB ID 3inw

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