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3irm
From Proteopedia
(Difference between revisions)
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<StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRM FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [https://pdbe.org/3irm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [https://www.ebi.ac.uk/pdbsum/3irm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [https://pdbe.org/3irm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [https://www.ebi.ac.uk/pdbsum/3irm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DRTS_TRYCR DRTS_TRYCR] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Trycr]] | ||
| - | [[Category: Chitnumsub, P]] | ||
| - | [[Category: Yuthavong, Y]] | ||
| - | [[Category: Yuvaniyama, J]] | ||
| - | [[Category: Dhfr-ts antifolate complex]] | ||
| - | [[Category: Methyltransferase]] | ||
| - | [[Category: Multifunctional enzyme]] | ||
| - | [[Category: Nadp]] | ||
| - | [[Category: Nucleotide biosynthesis]] | ||
| - | [[Category: One-carbon metabolism]] | ||
| - | [[Category: Oxidoreductase]] | ||
| - | [[Category: Transferase]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
| + | [[Category: Chitnumsub P]] | ||
| + | [[Category: Yuthavong Y]] | ||
| + | [[Category: Yuvaniyama J]] | ||
Current revision
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil
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