3isq

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Current revision (16:02, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3isq' size='340' side='right'caption='[[3isq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='3isq' size='340' side='right'caption='[[3isq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3isq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3isq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxyphenylpyruvate_dioxygenase 4-hydroxyphenylpyruvate dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.27 1.13.11.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isq OCA], [https://pdbe.org/3isq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isq RCSB], [https://www.ebi.ac.uk/pdbsum/3isq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isq OCA], [https://pdbe.org/3isq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isq RCSB], [https://www.ebi.ac.uk/pdbsum/3isq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/HPPD_HUMAN HPPD_HUMAN]] Defects in HPD are the cause of tyrosinemia type 3 (TYRO3) [MIM:[https://omim.org/entry/276710 276710]]. TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation.<ref>PMID:10942115</ref> <ref>PMID:11073718</ref> Defects in HPD are a cause of hawkinsinuria (HAWK) [MIM:[https://omim.org/entry/140350 140350]]. HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine.<ref>PMID:11073718</ref>
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[https://www.uniprot.org/uniprot/HPPD_HUMAN HPPD_HUMAN] Defects in HPD are the cause of tyrosinemia type 3 (TYRO3) [MIM:[https://omim.org/entry/276710 276710]. TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation.<ref>PMID:10942115</ref> <ref>PMID:11073718</ref> Defects in HPD are a cause of hawkinsinuria (HAWK) [MIM:[https://omim.org/entry/140350 140350]. HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine.<ref>PMID:11073718</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HPPD_HUMAN HPPD_HUMAN]] Key enzyme in the degradation of tyrosine.
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[https://www.uniprot.org/uniprot/HPPD_HUMAN HPPD_HUMAN] Key enzyme in the degradation of tyrosine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4-hydroxyphenylpyruvate dioxygenase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bray, J E]]
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[[Category: Bray JE]]
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[[Category: Cocking, R]]
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[[Category: Cocking R]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Kavanagh KL]]
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[[Category: Kavanagh, K L]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Pilka ES]]
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[[Category: Pilka, E S]]
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[[Category: Shafqat N]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Shafqat, N]]
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[[Category: Yue WW]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Yue, W W]]
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[[Category: Dioxygenase]]
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[[Category: Disease mutation]]
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[[Category: Hydroxyphenylpyruvate]]
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[[Category: Iron]]
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[[Category: Mental retardation]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Phenylalanine catabolism]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Tyrosine catabolism]]
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[[Category: Tyrosine metabolism]]
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Current revision

Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase

PDB ID 3isq

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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