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3iya

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3iya]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3iya]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iya OCA], [https://pdbe.org/3iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iya RCSB], [https://www.ebi.ac.uk/pdbsum/3iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iya ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 22&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iya OCA], [https://pdbe.org/3iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iya RCSB], [https://www.ebi.ac.uk/pdbsum/3iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iya ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
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[https://www.uniprot.org/uniprot/E7FLK7_9FLAV E7FLK7_9FLAV]
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, J]]
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[[Category: Chen J]]
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[[Category: Chipman, P R]]
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[[Category: Chipman PR]]
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[[Category: Holdaway, H A]]
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[[Category: Holdaway HA]]
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[[Category: Kuhn, R J]]
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[[Category: Kuhn RJ]]
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[[Category: Rossmann, M G]]
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[[Category: Rossmann MG]]
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[[Category: Yu, I]]
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[[Category: Yu I]]
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[[Category: Icosahedral virus]]
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[[Category: Prm]]
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[[Category: Virus]]
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Revision as of 14:11, 24 January 2024

Association of the pr peptides with dengue virus blocks membrane fusion at acidic pH

3iya, resolution 22.00Å

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OCA

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