3j4j

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<SX load='3j4j' size='340' side='right' viewer='molstar' caption='[[3j4j]], [[Resolution|resolution]] 11.50&Aring;' scene=''>
<SX load='3j4j' size='340' side='right' viewer='molstar' caption='[[3j4j]], [[Resolution|resolution]] 11.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J4J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J4J FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b3x|4b3x]], [[4b48|4b48]], [[1d1n|1d1n]], [[4kjz|4kjz]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">infB, TTHA0699 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j4j OCA], [https://pdbe.org/3j4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j4j RCSB], [https://www.ebi.ac.uk/pdbsum/3j4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j4j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j4j OCA], [https://pdbe.org/3j4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j4j RCSB], [https://www.ebi.ac.uk/pdbsum/3j4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j4j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IF2_THET8 IF2_THET8]] One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
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[https://www.uniprot.org/uniprot/IF2_THET8 IF2_THET8] One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thet8]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Billas, I M.L]]
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[[Category: Billas IML]]
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[[Category: Eiler, D]]
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[[Category: Eiler D]]
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[[Category: Fabbretti, A]]
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[[Category: Fabbretti A]]
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[[Category: Gualerzi, C O]]
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[[Category: Gualerzi CO]]
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[[Category: Hazemann, I]]
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[[Category: Hazemann I]]
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[[Category: Klaholz, B P]]
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[[Category: Klaholz BP]]
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[[Category: Marzi, S]]
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[[Category: Marzi S]]
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[[Category: Myasnikov, A]]
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[[Category: Myasnikov A]]
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[[Category: Puglisi, J D]]
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[[Category: Puglisi JD]]
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[[Category: Roblin, P]]
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[[Category: Roblin P]]
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[[Category: Simonetti, A]]
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[[Category: Simonetti A]]
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[[Category: Steitz, T A]]
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[[Category: Steitz TA]]
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[[Category: Tsai, A]]
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[[Category: Tsai A]]
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[[Category: Vaiana, A C]]
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[[Category: Vaiana AC]]
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[[Category: Fmet-trna binding]]
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[[Category: Gtp-binding protein]]
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[[Category: If2]]
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[[Category: Ribosome binding]]
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[[Category: Translation]]
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Revision as of 14:15, 24 January 2024

Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map

3j4j, resolution 11.50Å

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