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3j6b

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<SX load='3j6b' size='340' side='right' viewer='molstar' caption='[[3j6b]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<SX load='3j6b' size='340' side='right' viewer='molstar' caption='[[3j6b]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j6b]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw3 1vw3] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw4 1vw4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j6b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw3 1vw3] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw4 1vw4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6b OCA], [https://pdbe.org/3j6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6b RCSB], [https://www.ebi.ac.uk/pdbsum/3j6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6b OCA], [https://pdbe.org/3j6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6b RCSB], [https://www.ebi.ac.uk/pdbsum/3j6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RTC6_YEAST RTC6_YEAST]] Probable component of the mitochondrial large ribosomal subunit involved in ribosome biogenesis and translation. May be involved in a process influencing telomere capping.<ref>PMID:9392081</ref> <ref>PMID:18845848</ref> <ref>PMID:20691087</ref> [[https://www.uniprot.org/uniprot/MHR1_YEAST MHR1_YEAST]] Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells.<ref>PMID:11121487</ref> <ref>PMID:9736700</ref> <ref>PMID:7664749</ref> <ref>PMID:12198175</ref> <ref>PMID:12034822</ref> <ref>PMID:14565971</ref> <ref>PMID:16337661</ref> [[https://www.uniprot.org/uniprot/RM36_YEAST RM36_YEAST]] Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions.<ref>PMID:11259585</ref> <ref>PMID:15166137</ref> [[https://www.uniprot.org/uniprot/IMG1_YEAST IMG1_YEAST]] Essential for respiration.<ref>PMID:8771712</ref> [[https://www.uniprot.org/uniprot/RM06_YEAST RM06_YEAST]] Indispensable for mitochondrial function.
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[https://www.uniprot.org/uniprot/RML2_YEAST RML2_YEAST]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Amunts, A]]
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[[Category: Amunts A]]
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[[Category: Bai, X C]]
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[[Category: Bai XC]]
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[[Category: Brown, A]]
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[[Category: Brown A]]
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[[Category: Emsley, P]]
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[[Category: Emsley P]]
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[[Category: Hussain, T]]
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[[Category: Hussain T]]
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[[Category: Llacer, J L]]
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[[Category: Llacer JL]]
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[[Category: Long, F]]
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[[Category: Long F]]
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[[Category: Murshudov, G]]
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[[Category: Murshudov G]]
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[[Category: Ramakrishnan, V]]
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[[Category: Ramakrishnan V]]
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[[Category: Scheres, S H.W]]
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[[Category: Scheres SHW]]
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[[Category: Large subunit]]
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[[Category: Mitochondrial ribosome]]
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[[Category: Protein-rna complex]]
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[[Category: Ribosome]]
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Revision as of 14:16, 24 January 2024

Structure of the yeast mitochondrial large ribosomal subunit

3j6b, resolution 3.20Å

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