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==Introduction ==
==Introduction ==
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Titin, (TITN) also known as Connectin (PDB 3b43) is a human protein, unique for its large size. It is the largest known protein chain in the entire human body, comprising over 34,000 amino acids and holding a molecular weight of 3800 kD. Titin is found within muscle fibers and classified as a connectin protein. An adult human that weighs 80 kg may contain almost half a kilogram of Titin, <ref name="Labeit">DOI: 10.1161/01.res.80.2.290</ref>
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Titin, (TITN) also known as Connectin (PDB 3b43) is a human protein, unique for its large size. It is the largest known protein chain in the entire human body, comprising over 34,000 amino acids and holding a molecular weight of 3800 kD. Titin is found within muscle fibers and classified as a connectin protein. An adult human that weighs 80 kg may contain almost half a kilogram of Titin, making it extremely abundant as well. <ref name="Labeit">DOI: 10.1161/01.res.80.2.290</ref>
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making it extremely abundant as well.
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Revision as of 22:02, 21 April 2022

Titin

Caption for this structure

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References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. 3.0 3.1 Labeit S, Kolmerer B, Linke WA. The giant protein titin. Emerging roles in physiology and pathophysiology. Circ Res. 1997 Feb;80(2):290-4. doi: 10.1161/01.res.80.2.290. PMID:9012751 doi:http://dx.doi.org/10.1161/01.res.80.2.290

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Benjamin Prywitch

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