Sphingosine kinase
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | '''Sphingolipids''' are a class of lipids, containing a sphingosine base moiety, essential for eukaryotic cell membrane structure and function. <ref name="futerman">PMID:15289826</ref> Importantly, sphingolipids can additionally act as critical signaling molecules used in many eukaryotic homeostatic cellular processes, such as inflammation, proliferation, apoptosis, cell migration, and '''pathogen defense'''. <ref name="futerman">PMID:15289826</ref> | + | '''Sphingolipids''' are a class of lipids, containing a sphingosine base moiety, essential for eukaryotic cell membrane structure and function. <ref name="futerman">PMID:15289826</ref> Importantly, sphingolipids can additionally act as critical signaling molecules used in many eukaryotic homeostatic cellular processes, such as inflammation, proliferation, apoptosis, cell migration, and '''pathogen defense'''. <ref name="futerman">PMID:15289826</ref> Because of this, it is critical for sphingolipids and their metabolizing enzymes to exist in a delicate homeostatic balance within the eukaryotic cell system. |
'''Sphingosine-1-Phosphate (S1P)''', a lipid within the sphingolipid class, is an important signaling molecule that can participate in intracellular and extracellular signaling. <ref name="futerman">PMID:15289826</ref> <ref name="Spiegel">PMID:12728273</ref> S1P is critical not only to intracellular eukaryotic cell survival and function but is pivotal to eliciting the immune response, particularly as a mechanism to pathogen defense. <ref name="Spiegel">PMID:12728273</ref> '''Sphingosine Kinase''', existing in two isoenzyme forms, SphK1 and SphK2, '''creates S1P via the phosphorylation of sphingosine''', the base moiety of all sphingolipids. <ref name="Spiegel">PMID:12728273</ref> | '''Sphingosine-1-Phosphate (S1P)''', a lipid within the sphingolipid class, is an important signaling molecule that can participate in intracellular and extracellular signaling. <ref name="futerman">PMID:15289826</ref> <ref name="Spiegel">PMID:12728273</ref> S1P is critical not only to intracellular eukaryotic cell survival and function but is pivotal to eliciting the immune response, particularly as a mechanism to pathogen defense. <ref name="Spiegel">PMID:12728273</ref> '''Sphingosine Kinase''', existing in two isoenzyme forms, SphK1 and SphK2, '''creates S1P via the phosphorylation of sphingosine''', the base moiety of all sphingolipids. <ref name="Spiegel">PMID:12728273</ref> | ||
Revision as of 17:50, 25 April 2022
Structure
| |||||||||||
References
- ↑ 1.0 1.1 1.2 Futerman AH, Hannun YA. The complex life of simple sphingolipids. EMBO Rep. 2004 Aug;5(8):777-82. doi: 10.1038/sj.embor.7400208. PMID:15289826 doi:http://dx.doi.org/10.1038/sj.embor.7400208
- ↑ 2.0 2.1 2.2 Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003 May;4(5):397-407. doi: 10.1038/nrm1103. PMID:12728273 doi:http://dx.doi.org/10.1038/nrm1103
</StructureSection>
