1gyu

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[[Image:1gyu.jpg|left|200px]]
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[[Image:1gyu.png|left|200px]]
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==Overview==
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{{ABSTRACT_12176391}}
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The AP1 complex is one of a family of heterotetrameric clathrin-adaptor complexes involved in vesicular trafficking between the Golgi and endosomes. The complex has two large subunits, gamma and beta1, which can be divided into trunk, hinge, and appendage domains. The 1.8 A resolution structure of the gamma appendage is presented. The binding site for the known gamma appendage ligand gamma-synergin is mapped through creation of point mutations designed on the basis of the structure. We also show that Eps15, a protein believed to be involved in vesicle formation at the plasma membrane, is also a ligand of gamma appendage and binds to the same site as gamma-synergin. This observation explains the demonstrated brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi complex.
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==About this Structure==
==About this Structure==
1GYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1GYU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYU OCA].
1GYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1GYU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYU OCA].
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==Reference==
 
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Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12176391 12176391]
 
[[Category: Clathrin]]
[[Category: Clathrin]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Endocytosis]]
[[Category: Endocytosis]]
[[Category: Golgi]]
[[Category: Golgi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:11:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:26:44 2008''

Revision as of 14:26, 26 June 2008

Image:1gyu.png

Template:STRUCTURE 1gyu

GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1


Template:ABSTRACT 12176391

About this Structure

1GYU is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1GYU with [Clathrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:26:44 2008

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