1gz6

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{{STRUCTURE_1gz6| PDB=1gz6 | SCENE= }}
{{STRUCTURE_1gz6| PDB=1gz6 | SCENE= }}
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'''(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2'''
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===(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2===
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==Overview==
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The crystal structure of (3R)-hydroxyacyl-CoA dehydrogenase of rat peroxisomal multifunctional enzyme type 2 (MFE-2) was solved at 2.38 A resolution. The catalytic entity reveals an alpha/beta short chain alcohol dehydrogenase/reductase (SDR) fold and the conformation of the bound nicotinamide adenine dinucleotide (NAD(+)) found in other SDR enzymes. Of great interest is the separate COOH-terminal domain, which is not seen in other SDR structures. This domain completes the active site cavity of the neighboring monomer and extends dimeric interactions. Peroxisomal diseases that arise because of point mutations in the dehydrogenase-coding region of the MFE-2 gene can be mapped to changes in amino acids involved in NAD(+) binding and protein dimerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 12517343 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12517343}}
==About this Structure==
==About this Structure==
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[[Category: Sdr]]
[[Category: Sdr]]
[[Category: Steroid biosynthesis]]
[[Category: Steroid biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:12:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:21:20 2008''

Revision as of 03:21, 1 July 2008

Image:1gz6.png

Template:STRUCTURE 1gz6

(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2

Template:ABSTRACT PUBMED 12517343

About this Structure

1GZ6 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution., Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T, Structure. 2003 Jan;11(1):87-97. PMID:12517343

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